Study links oral antibiotic use to possible painful side effect

Study links oral antibiotic use to possible painful side effect

After controlling for urinary tract infections, medications, diseases like gout and diabetes, and other variables, they found that exposure to any of five classes of antibiotics significantly increased the risk for kidney stones. Young people also seemed to be most susceptible to developing kidney stones after taking these medications, they add.

While scientists have known about the changes antibiotics have on the human microbiome - crucial to our day-to-day health - this is the first time that a disruption in the microbiome has been linked to the occurrence of kidney stones.

However, the authors of the new study note that the prevalence of kidney stones has risen by 70 percent in the past 3 decades - particularly among adolescents and young women. The condition is, however, associated with bacterial changes in the intestines and urinary tract, leading investigators to study the relationship between antibiotics and kidney stones.

Tasian along with his fellow mates is planning to go for full proof investigation of microbiomes in the children and adolescent's body in the near future. In such cases, a urologist may need to remove the kidney stones or break them into smaller pieces. The CHOP team is now taking a closer look at kids gut bacteria, both with and without kidney stones.


The researchers, led by the pediatrician-urologist Dr. Gregory Tazian of the Philadelphia Children's Hospital, who published the Journal of the American Society of Nephrology (JASN), analyzed data for almost 26,000 people with nephrolithiasis and 260,000 without kidney stones. The team matched 25,981 patients with nephrolithiasis to 259,797 controls by age, sex, and practice at the date of diagnosis (termed the index date). Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

But for those who took broad-spectrum penicillins the risk was slightly less, at 27pc higher than normal.

They believe that their findings should inform doctors' decisions when considering whether or not to prescribe antibiotics to children, as they are the greatest recipients of these drugs. The disorder of microbial communities can then lead to easier kidney stone formation.

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