Dad Can Pass on Ovarian Cancer Genes, Too

Dad Can Pass on Ovarian Cancer Genes, Too

A study by scientists in the United States came for the first time to show signs of a genetic risk that ovarian cancer, which is more common after menopause, should be inherited from the father, except from mother.

The latest findings appear in the journal PLoS Genetics.

16, 2018 A gene mutation that's passed down from a father is associated with earlier onset of ovarian cancer in daughters and prostate cancer in the father and his sons, a new study suggests.

It is inherited through the X-chromosome and is independent of other known susceptibility genes that women can already be tested for. They also sequenced portions of the X chromosome from 186 women affected by ovarian cancer.

Men pass on one X chromosome to their daughters. The studies led to an examination by researchers of whether genes on the X-chromosome, passed down through the father, may contribute to a daughter's risk of ovarian cancer.

Prof Eng said: "What we have to do next is make sure we have the right gene by sequencing more families". She said that this is important for risk estimation for women because in most women ovarian cancers are detected at later stages when treatment is hard with little chances of success. He's an assistant professor of oncology at Roswell Park Comprehensive Cancer Center, in Buffalo, N.Y.

Further sequencing enabled the identification of a previously unknown mutation on the X-chromosome that may be connected to cases of ovarian cancer that develop more than six years earlier than average. Researchers have now found that there are several cases of ovarian cancers where these BRCA genes may not be the carriers, but a separate gene may be the culprit.

"This finding has sparked a lot of discussion within our group about how to find these X-linked families", Eng said.

In addition to the MAGEC3 mutation, there are other more famous gene issues tied to ovarian cancer risks, known as BRCA1 and BRCA2.

"In future, this could help women with a family history of ovarian cancer better understand their risk of developing the disease. Further work is now needed to get a clearer picture of how the genetic faults uncovered in this research might affect inherited risk of ovarian cancer". The five-year survival rate after diagnosis of ovarian cancer is close to 50%. Annwen Jones, Chief Executive of Target Ovarian Cancer also lauded the study because it would shed light on ovarian cancer inheritance.

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